A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.
نویسندگان
چکیده
The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
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عنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 73 11 شماره
صفحات -
تاریخ انتشار 2009